INTERNATIONAL WORKSHOP ON METABOLISM, DIET AND CHRONIC DISEASE:
The perspective of cancer and cardiovascular disease prevention
There is overwhelming observational evidence that sedentary living, energy dense food and sugary drinks represent major causes of the increasing prevalence of excessive weight and obesity, and that obesity is associated with an increasing incidence of cancer and cardiovascular disease. In both genders, obesity-related cancers, namely breast, colorectal, kidney, endometrium, esophagus (adenocarcinomas), pancreas, prostate, gallbladder, liver and (most likely) bladder and ovary cancer, represent two thirds of total cancer incidence.
Similarly, obesity and body fat distribution represent important cardio-metabolic risk factors for a number of cardiovascular pathologies. Physical activity has been consistently associated with lower cancer incidence (mainly colorectal, breast and endometrium, butalsolung and pancreas) as well as cardiovascular disease.
Metabolic syndrome is a condition defined by the presence of three or more of the following factors: abdominal adiposity, hypertension, hyperglycaemia, hypertriglyceridaemia and lowserumlevels of HDL cholesterol. In combination with an underlying situation of insulin resistance it confers a high cardiovascular risk profile and is associated with cancer. Women with metabolic syndrome have higher breast cancer incidence than women without any metabolic syndrome factor. In men, metabolic syndrome is associated with high colon cancer incidence and mortality. Several studies analysed cancer and cardiovascular incidence or mortality in relation to specific components of the metabolic syndrome and have found a direct and independent relation between each component and those conditions.
The invited internationally recognized speakers will present data on topics which will include metabolic pathways associated with cancer and cardiovascular diseases, obesity and diabetes, oncogenic drivers and cell dismetabolism in cancer cells, the metformin anticancer data-biguanides and energy metabolism, metabolism-based cancer and cardiovascular disease prevention.